A Rare Case of Mixed Adenoneuroendocrine (MiNEN) Carcinoma of the Gall Bladder
Published: 2023-04-01
Page: 130-136
Issue: 2023 - Volume 6 [Issue 1]
H. E. Heng *
Department of Surgery, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia and Hepatopancreatobiliary Surgery Unit, Division of General Surgery, University Malaya Medical Centre, Kuala Lumpur, Malaysia.
S. F. Chiew
Department of Pathology, Faculty of Medicine, University Malaya, Malaysia.
P. S. Koh
Department of Surgery, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia and Hepatopancreatobiliary Surgery Unit, Division of General Surgery, University Malaya Medical Centre, Kuala Lumpur, Malaysia.
*Author to whom correspondence should be addressed.
Abstract
Mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN) of the gall bladder is an extremely rare neoplasm of the gall bladder. We present a case of a 71-year-old female who came to our clinic with an incidental gall bladder mass and subsequently underwent laparoscopic radical cholecystectomy with liver cuff resection. Histology findings showed moderately differentiated carcinomatous component mixed with poorly differentiated large cell neuroendocrine carcinoma invading into muscular layer with clear resection margin (pT1bN0). Post operatively, she refused to undergo adjuvant therapy and unfortunately at 4 months after surgery she developed metastasis at the segment 5 of her liver. In conclusion, GB-MiNEN is an extremely rare and aggressive tumour of the gall bladder and surgery with adjuvant chemotherapy combined with somatostatin analogue may offer a better survival outcome.
Keywords: Mixed non-neuroendocrine neuroendocrine neoplasm, gallbladder cancer, liver metastasis