Primary Hepatic Neuroendocrine Tumor with Hepatocellular Carcinoma: A Rare Case Report
Asian Journal of Case Reports in Surgery,
Page 15-20
Abstract
Aim: Hepatocellular carcinoma is the most common primary liver malignancy followed by intrahepatic cholangiocarcinoma. The diagnosis of primary hepatic neuroendocrine tumor, a rare liver lesion, generally occurs during histological examination.
Case Report: A 48 year old male patient presented with a lesion in the segment 5/6 of liver clinically and imaging features suggestive of Hepatocellular carcinoma. He underwent resection of the lesion. Final histopathological analysis of the lesion showed combined Hepatocellular carcinoma and neuroendocrine tumor. DOTANAC scan was done postoperatively which confirmed primary hepatic neuroendocrine tumor by ruling out primary neuroendocrine tumor elsewhere. He is currently on adjuvant chemotherapy.
Discussion and Conclusion: Primary hepatic neuroendocrine tumor is a rare malignancy. It is mandatory to search for primary neuroendocrine tumors in rest of the gastrointestinal system before making the diagnosis. Combined Hepatocellular carcinoma and primary hepatic neuroendocrine tumor is a rare tumor which needs multidisciplinary team discussion to formulate treatment plan.
Keywords:
- Hepatocellular carcinoma
- hepatic neuroendocrine tumor
- Ki 67
- Hep Par
- CD 56
- synaptophysin
- Arginase
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